2009 IMAG Futures Report - Challenges | Interagency Modeling and Analysis Group

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2009 IMAG Futures Report Challenges/PAR-15-085 bullets

1) Next-generation multiscale models that integrate between different scientific fields (e.g. cardiovascular and neuroscience) and predict integrated functions

BEARD, DANIEL A (contact); KASSAB, GHASSAN S - Coronary Blood Flow: Integrated Theory and Experiments
BLEMKER, SILVIA SALINAS (contact); PEIRCE-COTTLER, SHAYN - Multiscale Modeling for Treatment Discovery in Duchenne Muscular Dystrophy
BLUESTEIN, DANNY - Multiscale Modeling of Blood Flow and Platelet Mediated Thrombosis
CARLSON, ROSS P (contact); FIELDS, MATTHEW W; HANLEY, LUKE ; HENSON, MICHAEL - Predictive Multiscale Modeling of Microbial Consortia Biofilms
DHAHER, YASIN YOUSEF (contact); THELEN, DARRYL G - A Multi-Scale Modeling Construct of Knee Mechanics following ACL Reconstruction
DIAMOND, SCOTT L - Multiscale Analysis of Trauma
GLAZIER, JAMES ALEXANDER (contact); DUNN, KENNETH W; KLAUNIG, JAMES E - Development of a Multiscale Mechanistic Simulation of Acetaminophen Induced Liver
HAUGH, JASON M - Multiscale Modeling of Wound Healing
KAPLAN, DAVID L (contact); BUEHLER, MARKUS J - Models to Predict Protein Biomaterial Performance
KIRSCHNER, DENISE E (contact); DARTOIS, VERONIQUE ; FLYNN, JOANNE L; LINDERMAN, JENNIFER JEAN - A Multi-scale systems pharmacology approach to TB therapy
LAZZI, GIANLUCA (contact); BERGER, THEODORE W - Predictive modeling of bioelectric activity on mammalian multilayered neuronal st
LEDERER, W JONATHAN (contact); JAFRI, MOHSIN SALEET; MANNELLA, CARMEN A - Multiscale spatiotemporal modeling of cardiac mitochondria
LYTTON, WILLIAM W - Microconnectomics of neocortex: a multiscale computer model
SANGER, TERENCE D (contact); GISZTER, SIMON F - Multiscale models of neural population control in spinal cord
SCHWABER, JAMES (contact); VADIGEPALLI, RAJANIKANTH - Multiscale Model of the Vagal Outflow to the Heart
SECOMB, TIMOTHY W - Multiscale modeling of cerebral blood flow and oxygen transport
YANKEELOV, THOMAS E (contact); QUARANTA, VITO - Image Driven Multi-Scale Modeling to Predict Treatment Response in Breast Cancer
ZAMAN, MUHAMMAD HAMID (contact); GERTLER, FRANK B; KAMM, ROGER D; LAUFFENBURGER, DOUGLAS A - Modeling bi-directional signaling and cytoskeletal dynamics in 3D cell migrations
ZAWIEJA, DAVID CARL (contact); MOORE, JAMES E - Transport Phenomena in the Lymphatic System
BORON, WALTER F. (contact); TAJKHORSHID, EMAD; SOMERSALO, ERKKI - Multi-scale modeling of gas transport through channels in living cells

2) Higher level models and modeling approaches that integrate multiple physiological (and possibly psychological) systems in order to better understand the human response (e.g. to extended space flight, and other unique environments)

BLEMKER, SILVIA SALINAS (contact); PEIRCE-COTTLER, SHAYN - Multiscale Modeling for Treatment Discovery in Duchenne Muscular Dystrophy
DICK, THOMAS E - Modeling Brainstem Inflammations Role in Systemic Dysfunction during Sepsis
FIGUEROA, CARLOS ALBERTO (contact); BAEK, SEUNGIK ; DORFMAN, ADAM LEE - Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension

3) Novel methods to fuse data-rich and data-poor scales to enable predictive modeling

BASANTA GUTIERREZ, DAVID (contact); LYNCH, CONOR C - Multiscale Modeling of Bone Environment Responses to Metastatic Prostate Cancer
BLEMKER, SILVIA SALINAS (contact); PEIRCE-COTTLER, SHAYN - Multiscale Modeling for Treatment Discovery in Duchenne Muscular Dystrophy
CANNON, WILLIAM R (contact); DUNLAP, JAY C - Multiscale Modeling of Circadian Rhythms
CARLSON, ROSS P (contact); FIELDS, MATTHEW W; HANLEY, LUKE ; HENSON, MICHAEL - Predictive Multiscale Modeling of Microbial Consortia Biofilms
FIGUEROA, CARLOS ALBERTO (contact); BAEK, SEUNGIK ; DORFMAN, ADAM LEE - Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension
GLAZIER, JAMES ALEXANDER (contact); DUNN, KENNETH W; KLAUNIG, JAMES E - Development of a Multiscale Mechanistic Simulation of Acetaminophen Induced Liver
HAUGH, JASON M - Multiscale Modeling of Wound Healing
HENSON, MICHAEL (contact); HERZOG, ERIK ; KEVREKIDIS, YANNIS G - Multiscale Modeling of the Mammalian Circadian Clock: The Role of GABA Signaling
KIRSCHNER, DENISE E (contact); DARTOIS, VERONIQUE ; FLYNN, JOANNE L; LINDERMAN, JENNIFER JEAN - A Multi-scale systems pharmacology approach to TB therapy
LEDERER, W JONATHAN (contact); JAFRI, MOHSIN SALEET; MANNELLA, CARMEN A - Multiscale spatiotemporal modeling of cardiac mitochondria
LIN, CHING-LONG - An integrative statistics-guided image-based multi-scale lung model
LYTTON, WILLIAM W - Microconnectomics of neocortex: a multiscale computer model
SANGER, TERENCE D (contact); GISZTER, SIMON F - Multiscale models of neural population control in spinal cord
SAUNDERS, MICHAEL ALAN - Multiscale Molecular Systems Biology: Reconstruction and Model Optimization
ZAWIEJA, DAVID CARL (contact); MOORE, JAMES E - Transport Phenomena in the Lymphatic System
BORON, WALTER F. (contact); TAJKHORSHID, EMAD; SOMERSALO, ERKKI - Multi-scale modeling of gas transport through channels in living cells

4) Novel methods to fuse biological and/or behavioral processes and mechanisms to model outcomes as a result of various interventions

ALBER, MARK - Multiscale modeling and empirical study of a mechanism limiting blood clot growth
BLEMKER, SILVIA SALINAS (contact); PEIRCE-COTTLER, SHAYN - Multiscale Modeling for Treatment Discovery in Duchenne Muscular Dystrophy
BLUESTEIN, DANNY - Multiscale Modeling of Blood Flow and Platelet Mediated Thrombosis
CAMPBELL, KENNETH S (contact); WENK, JONATHAN F - Multiscale modeling of inherited cardiomyopathies and therapeutic interventions
CARLSON, ROSS P (contact); FIELDS, MATTHEW W; HANLEY, LUKE ; HENSON, MICHAEL - Predictive Multiscale Modeling of Microbial Consortia Biofilms
DHAHER, YASIN YOUSEF (contact); THELEN, DARRYL G - A Multi-Scale Modeling Construct of Knee Mechanics following ACL Reconstruction
DICK, THOMAS E - Modeling Brainstem Inflammations Role in Systemic Dysfunction during Sepsis
FIGUEROA, CARLOS ALBERTO (contact); BAEK, SEUNGIK ; DORFMAN, ADAM LEE - Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension
HOLMES, JEFFREY W - Multiscale Models of Cardiac Growth, Remodeling, and Myocardial Infarction
LAZZI, GIANLUCA (contact); BERGER, THEODORE W - Predictive modeling of bioelectric activity on mammalian multilayered neuronal st
LIN, CHING-LONG - An integrative statistics-guided image-based multi-scale lung model
LYTTON, WILLIAM W - Microconnectomics of neocortex: a multiscale computer model
SANGER, TERENCE D (contact); GISZTER, SIMON F - Multiscale models of neural population control in spinal cord
YANKEELOV, THOMAS E (contact); QUARANTA, VITO - Image Driven Multi-Scale Modeling to Predict Treatment Response in Breast Cancer

5) Reproducible and reusable multiscale models that will be integrated and adopted into model-poor fields (e.g. tissue engineering, regenerative medicine, drug and gene delivery, preventive interventions)

ALBER, MARK - Multiscale modeling and empirical study of a mechanism limiting blood clot growt
BASSINGTHWAIGHTE, JAMES B (contact); BEARD, DANIEL A; DASH, RANJAN K; MCCULLOCH, ANDREW D - Analyzing the Cardiac Power Grid: Adaptive responses to fluctuating local demand
CANNON, WILLIAM R (contact); DUNLAP, JAY C - Multiscale Modeling of Circadian Rhythms
ECKMANN, DAVID M (contact); RADHAKRISHNAN, RAVI - Bridging multiple scales in modeling targeted drug nanocarrier delivery
GENIN, GUY M (contact); THOMOPOULOS, STAVROS - Cross-scale interactions between mineral and collagen for tendon-bone attachment
GLAZIER, JAMES ALEXANDER (contact); DUNN, KENNETH W; KLAUNIG, JAMES E - Development of a Multiscale Mechanistic Simulation of Acetaminophen Induced Liver
HAUGH, JASON M - Multiscale Modeling of Wound Healing
KAPLAN, DAVID L (contact); BUEHLER, MARKUS J - Models to Predict Protein Biomaterial Performance
KARNIADAKIS, GEORGE (contact); DAO, MING ; HIGGINS, JOHN MATTHEW; VEKILOV, PETER G - Multiscale Modeling of Sickle Cell Anemia: Methods and Validation
KIRSCHNER, DENISE E (contact); DARTOIS, VERONIQUE ; FLYNN, JOANNE L; LINDERMAN, JENNIFER JEAN - A Multi-scale systems pharmacology approach to TB therapy
LAUBENBACHER, REINHARD (contact); MEHRAD, BORNA ; SCHROEDER, WILLIAM J - Modular design of multiscale models, with an application to the innate immune response to fungal respiratory pathogens.
LYTTON, WILLIAM W - Microconnectomics of neocortex: a multiscale computer model
SAUNDERS, MICHAEL ALAN - Multiscale Molecular Systems Biology: Reconstruction and Model Optimization
VADIGEPALLI, RAJANIKANTH (contact); HOEK, JOANNES B - Modeling Multiscale Control of Liver Regeneration
ZAWIEJA, DAVID CARL (contact); MOORE, JAMES E - Transport Phenomena in the Lymphatic System
ZHOU, XIAOBO (contact); YANG, YUNZHI - Systems Modeling Guided Bone regeneration

6) Multiscale models strongly coupled with standardized protocols for model-driven data collectio

BAROCAS, VICTOR H (contact); WINKELSTEIN, BETH A - Multiscale Modeling of Facet Capsule Mechanobiology
BASSINGTHWAIGHTE, JAMES B (contact); BEARD, DANIEL A; DASH, RANJAN K; MCCULLOCH, ANDREW D - Analyzing the Cardiac Power Grid: Adaptive responses to fluctuating local demand
CANNON, WILLIAM R (contact); DUNLAP, JAY C - Multiscale Modeling of Circadian Rhythms
FIGUEROA, CARLOS ALBERTO (contact); BAEK, SEUNGIK ; DORFMAN, ADAM LEE - Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension
KAPLAN, DAVID L (contact); BUEHLER, MARKUS J - Models to Predict Protein Biomaterial Performance
KARNIADAKIS, GEORGE (contact); DAO, MING ; HIGGINS, JOHN MATTHEW; VEKILOV, PETER G - Multiscale Modeling of Sickle Cell Anemia: Methods and Validation
KIRSCHNER, DENISE E (contact); DARTOIS, VERONIQUE ; FLYNN, JOANNE L; LINDERMAN, JENNIFER JEAN - A Multi-scale systems pharmacology approach to TB therapy
LEDERER, W JONATHAN (contact); JAFRI, MOHSIN SALEET; MANNELLA, CARMEN A - Multiscale spatiotemporal modeling of cardiac mitochondria
LYTTON, WILLIAM W - Microconnectomics of neocortex: a multiscale computer model
SAUNDERS, MICHAEL ALAN - Multiscale Molecular Systems Biology: Reconstruction and Model Optimization
SECOMB, TIMOTHY W - Multiscale modeling of cerebral blood flow and oxygen transport
SOBIE, ERIC A (contact); CHRISTINI, DAVID J - Multiscale modeling to map cardiac electrophysiology between species
YANKEELOV, THOMAS E (contact); QUARANTA, VITO - Image Driven Multi-Scale Modeling to Predict Treatment Response in Breast Cancer
ZAWIEJA, DAVID CARL (contact); MOORE, JAMES E - Transport Phenomena in the Lymphatic System
BORON, WALTER F. (contact); TAJKHORSHID, EMAD; SOMERSALO, ERKKI - Multi-scale modeling of gas transport through channels in living cells

7) Implementing virtual clinical trials with multiscale models to predict outcomes

CLANCY, COLLEEN E - Predictive multiscale in silico cardio-pharmacology
GLAZIER, JAMES ALEXANDER (contact); DUNN, KENNETH W; KLAUNIG, JAMES E - Development of a Multiscale Mechanistic Simulation of Acetaminophen Induced Liver
KIRSCHNER, DENISE E (contact); DARTOIS, VERONIQUE ; FLYNN, JOANNE L; LINDERMAN, JENNIFER JEAN - A Multi-scale systems pharmacology approach to TB therapy
YANKEELOV, THOMAS E (contact); QUARANTA, VITO - Image Driven Multi-Scale Modeling to Predict Treatment Response in Breast Cancer

8) Problem-driven multiscale models that require high performance computing

ALBER, MARK - Multiscale modeling and empirical study of a mechanism limiting blood clot growth
BASANTA GUTIERREZ, DAVID (contact); LYNCH, CONOR C - Multiscale Modeling of Bone Environment Responses to Metastatic Prostate Cancer
BLUESTEIN, DANNY - Multiscale Modeling of Blood Flow and Platelet Mediated Thrombosis
BAROCAS, VICTOR H (contact); WINKELSTEIN, BETH A - Multiscale Modeling of Facet Capsule Mechanobiology
CLANCY, COLLEEN E - Predictive multiscale in silico cardio-pharmacology
DHAHER, YASIN YOUSEF (contact); THELEN, DARRYL G - A Multi-Scale Modeling Construct of Knee Mechanics following ACL Reconstruction
FIGUEROA, CARLOS ALBERTO (contact); BAEK, SEUNGIK ; DORFMAN, ADAM LEE - Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension
GUCCIONE, JULIUS MATTEO (contact); KASSAB, GHASSAN S; KUHL, ELLEN - Multi-Scale Laws of Myocardial Growth and Remodeling
HAUGH, JASON M - Multiscale Modeling of Wound Healing
KARNIADAKIS, GEORGE (contact); DAO, MING ; HIGGINS, JOHN MATTHEW; VEKILOV, PETER G - Multiscale Modeling of Sickle Cell Anemia: Methods and Validation
KIRSCHNER, DENISE E (contact); DARTOIS, VERONIQUE ; FLYNN, JOANNE L; LINDERMAN, JENNIFER JEAN - A Multi-scale systems pharmacology approach to TB therapy
LAZZI, GIANLUCA (contact); BERGER, THEODORE W - Predictive modeling of bioelectric activity on mammalian multilayered neuronal st
LIN, CHING-LONG - An integrative statistics-guided image-based multi-scale lung model
LYTTON, WILLIAM W - Microconnectomics of neocortex: a multiscale computer model
SECOMB, TIMOTHY W - Multiscale modeling of cerebral blood flow and oxygen transport
ZAWIEJA, DAVID CARL (contact); MOORE, JAMES E - Transport Phenomena in the Lymphatic System
BORON, WALTER F. (contact); TAJKHORSHID, EMAD; SOMERSALO, ERKKI - Multi-scale modeling of gas transport through channels in living cells

9) Model predictions that drive a community of experimentalists towards systematic testing and validatio

ALBER, MARK - Multiscale modeling and empirical study of a mechanism limiting blood clot growth
BASANTA GUTIERREZ, DAVID (contact); LYNCH, CONOR C - Multiscale Modeling of Bone Environment Responses to Metastatic Prostate Cancer
BASSINGTHWAIGHTE, JAMES B (contact); BEARD, DANIEL A; DASH, RANJAN K; MCCULLOCH, ANDREW D - Analyzing the Cardiac Power Grid: Adaptive responses to fluctuating local demand
BEARD, DANIEL A (contact); KASSAB, GHASSAN S - Coronary Blood Flow: Integrated Theory and Experiments
BLUESTEIN, DANNY - Multiscale Modeling of Blood Flow and Platelet Mediated Thrombosis
CANNON, WILLIAM R (contact); DUNLAP, JAY C - Multiscale Modeling of Circadian Rhythms
DIAMOND, SCOTT L - Multiscale Analysis of Trauma
DICK, THOMAS E - Modeling Brainstem Inflammations Role in Systemic Dysfunction during Sepsis
GENIN, GUY M (contact); THOMOPOULOS, STAVROS - Cross-scale interactions between mineral and collagen for tendon-bone attachment
HAUGH, JASON M - Multiscale Modeling of Wound Healing
JARON, DOV - Multiscale, Transport-Dependent NO Signaling: Cells to Vascular Networks
KAPLAN, DAVID L (contact); BUEHLER, MARKUS J - Models to Predict Protein Biomaterial Performance
KARNIADAKIS, GEORGE (contact); DAO, MING ; HIGGINS, JOHN MATTHEW; VEKILOV, PETER G - Multiscale Modeling of Sickle Cell Anemia: Methods and Validation
KIRSCHNER, DENISE E (contact); DARTOIS, VERONIQUE ; FLYNN, JOANNE L; LINDERMAN, JENNIFER JEAN - A Multi-scale systems pharmacology approach to TB therapy
LAZZI, GIANLUCA (contact); BERGER, THEODORE W - Predictive modeling of bioelectric activity on mammalian multilayered neuronal st
LEDERER, W JONATHAN (contact); JAFRI, MOHSIN SALEET; MANNELLA, CARMEN A - Multiscale spatiotemporal modeling of cardiac mitochondria
LIN, CHING-LONG - An integrative statistics-guided image-based multi-scale lung model
SECOMB, TIMOTHY W - Multiscale modeling of cerebral blood flow and oxygen transport
SOBIE, ERIC A (contact); CHRISTINI, DAVID J - Multiscale modeling to map cardiac electrophysiology between species
ZAMAN, MUHAMMAD HAMID (contact); GERTLER, FRANK B; KAMM, ROGER D; LAUFFENBURGER, DOUGLAS A - Modeling bi-directional signaling and cytoskeletal dynamics in 3D cell migrations
ZAWIEJA, DAVID CARL (contact); MOORE, JAMES E - Transport Phenomena in the Lymphatic System
BORON, WALTER F. (contact); TAJKHORSHID, EMAD; SOMERSALO, ERKKI - Multi-scale modeling of gas transport through channels in living cells

10) Predictive multiscale models that strongly incorporate uncertainty quantification

BASSINGTHWAIGHTE, JAMES B (contact); BEARD, DANIEL A; DASH, RANJAN K; MCCULLOCH, ANDREW D - Analyzing the Cardiac Power Grid: Adaptive responses to fluctuating local demand
CANNON, WILLIAM R (contact); DUNLAP, JAY C - Multiscale Modeling of Circadian Rhythms
FIGUEROA, CARLOS ALBERTO (contact); BAEK, SEUNGIK ; DORFMAN, ADAM LEE - Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension
GLAZIER, JAMES ALEXANDER (contact); DUNN, KENNETH W; KLAUNIG, JAMES E - Development of a Multiscale Mechanistic Simulation of Acetaminophen Induced Liver
KIRSCHNER, DENISE E (contact); DARTOIS, VERONIQUE ; FLYNN, JOANNE L; LINDERMAN, JENNIFER JEAN - A Multi-scale systems pharmacology approach to TB therapy
SANGER, TERENCE D (contact); GISZTER, SIMON F - Multiscale models of neural population control in spinal cord
YANKEELOV, THOMAS E (contact); QUARANTA, VITO - Image Driven Multi-Scale Modeling to Predict Treatment Response in Breast Cancer

11) Mechanistic multiscale models that bridge to the population level to capture more clinical and biological realism for the population

BASANTA GUTIERREZ, DAVID (contact); LYNCH, CONOR C - Multiscale Modeling of Bone Environment Responses to Metastatic Prostate Cancer
CORCORAN, TIMOTHY E (contact); PARKER, ROBERT S - Building Multilevel Models of Therapeutic Response in the Lungs
GLAZIER, JAMES ALEXANDER (contact); DUNN, KENNETH W; KLAUNIG, JAMES E - Development of a Multiscale Mechanistic Simulation of Acetaminophen Induced Liver
LIN, CHING-LONG - An integrative statistics-guided image-based multi-scale lung model
SOBIE, ERIC A (contact); CHRISTINI, DAVID J - Multiscale modeling to map cardiac electrophysiology between species
BORON, WALTER F. (contact); TAJKHORSHID, EMAD; SOMERSALO, ERKKI - Multi-scale modeling of gas transport through channels in living cells

12) Models that generate testable hypotheses regarding the biological underpinnings of behavioral and social phenomena and processes at the individual and population level

13) Models that describe mechanisms through which “outside-the-skin” factors, such as behavioral stressors, social bonding, parenting behavior, etc., can lead to “inside-the-skin” changes, such as in gene expression, the microbiome, or other factors that affect health or behavior

14) Models that provide innovative characterizations of interactions between individual-level behaviors, cognition, or affective processes and group-, market-, or population-level outcomes

LEE, BRUCE Y - Virtual Population Obesity Prevention (VPOP) Labs: Computational, Multi-Scale Models for Obesity Solutions

15) Models to explore underlying mechanisms of individual-, community-, or population-level preventive or therapeutic interventions

BLUESTEIN, DANNY - Multiscale Modeling of Blood Flow and Platelet Mediated Thrombosis
BAROCAS, VICTOR H (contact); WINKELSTEIN, BETH A - Multiscale Modeling of Facet Capsule Mechanobiology
FIGUEROA, CARLOS ALBERTO (contact); BAEK, SEUNGIK ; DORFMAN, ADAM LEE - Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension
HOLMES, JEFFREY W - Multiscale Models of Cardiac Growth, Remodeling, and Myocardial Infarction
~~KIRSCHNER, DENISE E (contact); DARTOIS, VERONIQUE ; FLYNN, JOANNE L; LINDERMAN, JENNIFER JEAN - A Multi-scale systems pharmacology approach to TB therapy~~
LEE, BRUCE Y - Virtual Population Obesity Prevention (VPOP) Labs: Computational, Multi-Scale Models for Obesity Solutions
LIN, CHING-LONG - An integrative statistics-guided image-based multi-scale lung model
LYTTON, WILLIAM W - Microconnectomics of neocortex: a multiscale computer model

16) Novel computational modeling approaches for big data that account for simultaneous sources of data on multiple scales; from biological and physiological measures, to social and psychological variables, and to environmental or contextual or societal level factors

BLUESTEIN, DANNY - Multiscale Modeling of Blood Flow and Platelet Mediated Thrombosis
CANNON, WILLIAM R (contact); DUNLAP, JAY C - Multiscale Modeling of Circadian Rhythms
LEE, BRUCE Y - Virtual Population Obesity Prevention (VPOP) Labs: Computational, Multi-Scale Models for Obesity Solutions

17) Multiscale models that characterize the implications of individual-level risks for collective outcomes, or the implications of systemic risks for individual behaviors and outcomes

GLAZIER, JAMES ALEXANDER (contact); DUNN, KENNETH W; KLAUNIG, JAMES E - Development of a Multiscale Mechanistic Simulation of Acetaminophen Induced Liver
HOLMES, JEFFREY W - Multiscale Models of Cardiac Growth, Remodeling, and Myocardial Infarction
LEE, BRUCE Y - Virtual Population Obesity Prevention (VPOP) Labs: Computational, Multi-Scale Models for Obesity Solutions

18) Predictive multiscale models to improve clinical workflow, standard operating procedures, patient-specific modeling for diagnosis and therapy planning

BAROCAS, VICTOR H (contact); WINKELSTEIN, BETH A - Multiscale Modeling of Facet Capsule Mechanobiology
CLANCY, COLLEEN E - Predictive multiscale in silico cardio-pharmacology
CORCORAN, TIMOTHY E (contact); PARKER, ROBERT S - Building Multilevel Models of Therapeutic Response in the Lungs
FIGUEROA, CARLOS ALBERTO (contact); BAEK, SEUNGIK ; DORFMAN, ADAM LEE - Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension
LAZZI, GIANLUCA (contact); BERGER, THEODORE W - Predictive modeling of bioelectric activity on mammalian multilayered neuronal st
YANKEELOV, THOMAS E (contact); QUARANTA, VITO - Image Driven Multi-Scale Modeling to Predict Treatment Response in Breast Cancer

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