Return to: 2011 MSM Consortium Meeting Agenda

Agenda Wednesday October 5

Breakfast on your own

8:30 – 9:00am Check-In (Room E), Set up Posters (Room D)

9:00 – 9:15am Welcome from IMAG and NHLBI (Room C)

Grace Peng (IMAG), Jennie Larkin (NHLBI)

9:15 - 10:15am Keynote Lecture: Modeling the Human Microbiome: From Enzymes to Super-Organisms

Elhanan Borenstein, University of Washington

10:15 – 10:30am Refreshments (Room E)

10:30 – 11:45am Theme 1 Presentations: Combining Data-Driven and Mechanistic Modeling Techniques (Part 1)

IMAG Moderator: Peter Lyster (NIGMS)

10:30-10:45am

Bruce Caswell - Multi-Scale DPD Models for Red Blood Cells in Health and Disease

10:45-11:00am

Vasilis Marmarelis - Synergistic use of data-based and mechanism-based modeling approaches

11:00-11:15am

Scott Diamond - Multiscale prediction of patient-specific clotting function under flow.

11:15-11:30am

Ahmet Erdemir - Chondrocyte Deformations as a Function of Tibiofemoral Joint Loading

11:30-11:45am

James Moore - Multi-Scale Modeling of Lymphatic System Pumping and Signaling

11:45 - 12:30pm Poster Flash Presentations

11:45-11:55am - - Theme 1 Posters: (2.5 mins each) - IMAG Moderator: Rocky Feuer (NCI)

1. David Eckmann, Ravi Radhakrishnan - Modeling the motion of a nanocarrier for targeted drug delivery

2. Teresa Pitts - Coordination of cough and swallow in vivo and in silico

3. Kung-Sik Chan - Lung-airway Data Interrogation via Cluster Analysis

4. Andrew Dolan, Scott Diamond - A Quantitative Molecular Signaling Model of Calcium Regulation in a Homeostatic and Activated Platelet

11:55-12:02pm - - Theme 2 Posters: (2.5 mins each)

5. Bruce Lindsey - Baroreceptor modulation of cough motor pattern: computational network model and in vivo experiments

6. Jennifer Linderman – The role of tumor necrosis factor in granuloma function and reactivation TB

7. Raj Vadigepalli and James Schwaber - In vivo variability of regulatory programs and single cell physiology in central homeostatic control circuits

12:03-12:30pm - - Non-Themed Posters (2.5 mins each)

8. Markus Buehler - Nonlinear behavior of silk minimizes damage and begets spider web robustness from the molecules up

9. Stacey D. Finley, Marianne O. Engel-Stefanini, P.I. Imoukhuede, and Aleksander S. Popel - Multiscale Compartment Model of VEGF Distribution in the Body: Applications to Cancer Therapy

10. Princess I. Imoukhuede and Aleksander S. Popel- Quantitative Experimental Characterization of Angiogenic Receptors for Systems Biology

11. Wonmuk Hwang - Elucidating the feedback between micro-mechanical environments and the nano-scale dynamics of biolaments

12. Tom Colace, MS Chatterjee, SL Diamond - Pairwise agonist screening and microfluidics reveal platelet function phenotype

13. Matthew H. Flamm, Talid Sinno, Scott L. Diamond - A Multiscale Model for Platelet Deposition

14. Dalin Tang - A Framework for Human Coronary Plaque Vulnerability Assessment Based on Patient-Specific Intravascular Ultrasound (IVUS) Imaging, Computational Modeling and Planar Biaxial Artery Material Properties

15. Roman S. Voronov, Timothy J. Stalker, Lawrence F. Brass, Scott L. Diamond - Image-based modeling as simple approach to studying thrombosis

16. Yaling Liu - Characterization of the Effects of Particle Shape and Blood Cells on Nanoparticle Delivery Efficiency

17. Yufang Jin - Targeting the Myocardial Infarction-Specific Protein Interaction Network Using Computational Analyses

18. Sriram Neelamegham - Systems Biology of Glycosylation

12:30 - 1:30pm Lunch on your own (cafeteria in building), View Posters (Room D)

1:30–2:45pm Theme 1 Presentations: Combining Data-Driven and Mechanistic Modeling Techniques (Part II)

IMAG Moderator: Tom Russell (NSF)

1:30-1:45pm

Yoram Vodovotz - Combining Data-Driven and Multiscale Mechanistic Modeling to Explore Endotoxin-Induced Inflammation in Swine

1:45-2:00pm

Roy Kerckhoffs - Patient-specific multi-scale modeling of cardiac resynchronization therapy for dyssynchronous heart failure

2:00-2:15pm

Ching-Long Lin - An Individual Multi-scale Image-based Lung Model and a Statistics-based Strategy of applying it to Population-based Assessment of Lung Functions

2:15-2:30pm

Katherine Zhang - An Integrative Multi-Scale Model of Extracellular Matrix Mechanics in Vascular Remodeling

2:30-2:45pm

Sasha Popel - Computational Modeling and Bioinformatics of Cancer Angiogenesis at the Molecular, Cellular, Tissue, and Whole-Body Scales

2:45 – 3:15pm Theme 1 Discussion

IMAG Moderators: Peter Lyster (NIGMS), Tom Russell (NSF), Rocky Feuer (NCI)

3:15 – 3:30pm Refreshments (Room E)

3:30-4:50pm All Attendee Discussion with Working Groups (20 mins each)

3:30-3:50pm - Multiscale Systems Biology Working Group

Dan Beard, Mike King, Sasha Popel

• Working group initiatives--seminars, wiki page, ABME special issue
• Soliciting feedback from attendees on our systems biology site: Is the material useful for researchers and trainees? What is missing? What should be focus on in 2012?

(Slides to be presented at the meeting: Media:Systems Biology WG Oct5.pdf)

3:50-4:10pm - Biomechanics Working Group

Ahmet Erdemir, Jay Humphrey

• Discussion on a new thematic monthly webinar series

4:10-4:30pm - Theoretical and Computational Methods

Suvranu De

• An edited book on multiscale modeling in biology that features algorithms and successful examples of multiscale coupling of at least two scales in a theoretically consistent manner. Discussions will center around possible authors/groups and sub-areas.
• Plan for next year's activities of the WG, especially how we couple with the other WGs

4:30-4:50pm - Population Modeling Working Group

Georg Luebeck, Stephen Eubank/Madhav Marathe

• Deriving population level phenomena from multiscale models of individual behavior. What are the challenges?

4:50 – 5:10pm Special Discussion: High-Performance Computing Challenges in MSM

Discussants: Gabrielle Allen (NSF-OCI), Susan Gregurick (DOE-BER)

5:10-5:15pm Closing Thoughts - Day 1

6:30pm Group Dinner in Downtown Bethesda

Shangri-La Indian Nepali Cuisine

7345-A Wisconsin Ave, Bethesda, MD 20814