Return to: 2011 MSM Consortium Meeting Agenda

Agenda Thursday, October 6

Breakfast on your own

8:00 – 8:15am Set up Posters (Room D)

8:15 – 8:30am - IMAG Initiatives - Grace Peng (IMAG) (Room C)

8:30 – 9:45am Theme 2 Presentations: What can we Learn from Simple Systems Models to Study Complex Systems (Breadth vs. Depth)

IMAG Moderators: Jennifer Couch (NCI), Susan Volman (NIDA)

8:30-8:45am

David Eckmann, Ravi Radhakrishnan - Top-down Multiscale Models and Free Energy Calculations of Multivalent Protein-Protein and Protein-Membrane Interactions in Nanocarrier Adhesion and Receptor Trafficking

8:45-9:00am

Mounya Elhilali - The Linear auditory cortex: how far can it take us in cocktail party scenes?

9:00-9:15am

Ilya Rybak - Multiscale modeling of the neural control of breathing: complex and simplified models

9:15-9:30

Bridget Wilson - Ovarian tumor attachment, invasion and vascularization reflect unique microenvironments in the peritoneum: Insights from intravital imaging and mathematical modeling

9:30-9:45am

Raimond Winslow - Redox Modification of the Arrhythmic Substrate in Heart Failure

9:45 – 10:15am Theme 2 Discussion

IMAG Moderators: Jennifer Couch (NCI), Susan Volman (NIDA)

10:15 – 10:30am Refreshments (Room E)

10:30 - 11:50pm Discussion with Working Groups (20 mins each)

10:30-10:50am - Model Sharing Working Group

Peter Hunter, Herbert Sauro

• Progress on model sharing through the VPH/Physiome
• Assessing the need for model sharing in the MSM Consortium

10:50-11:10am - Data Sharing Working Group

Roger Mark, Jim Bassingthwaighte, George Moody

• Is there a perceived need for data sharing in the modeling community?
  • For model development?
  • For model verification?
  • For data preservation? (To enhance the utility and comprehension of sharable models, store and share models and data combined to demonstrate the testing of models for validity and for precision in description.)
• What is PhysioNet? Could it be helpful?
• Would it make sense to identify one or two pilot studies?

11:00-11:30am - Computational Neuroscience Working Group

Ilya Rybak, James Bower

• Information/report on Multiscale Modeling Workshop at the Computational Neuroscience Conference (CNS'2011) in Stockholm
• Plans for further development multiscale modeling approaches in neuroscience

11:30-11:50am - Clinical and Translational Issues Working Group

Marc Garbey, Bill Lytton

• Translational MSM suffers from a dual burden: the difficulties of translating findings from bench to bedside, and the widespread incomprehension of computer modeling seen in both biomedical scientists and physicians; hence incomprehension^2
• However, the rise of individualized (personalized) medicine from the ashes of evidence-based medicine will require far more coordination and evaluation of data from each patient, ranging from the level of the genome on up to behavioral assessments. This is precisely what the combination of data-mining and MSM are designed to do.
• Our task is to begin to make these computational tools more accessible as an adjunct to clinical data gathering and data assessment. Here we can perhaps take a clue from rational pharmacotherapeutics, where advanced modeling techniques have found acceptance as part of ligand development.

11:50-12:00pm - Special Presentation by Dr. Tina Morrison, FDA

Enabling Faster and Better Medical Device Development and Evaluation via Computational Modeling and Simulation: FDA perspective

12:00 – 12:30pm MSM Consortium Meeting - Concurrent Session (Room C)

Grace Peng (IMAG)

• Consortium Goals and Structure

• New WGs

• Plans for 2012 MSM meeting

• IMAG and MSM Website & Wiki update – Stephanie Sabourin, wikimaster (NIBIB)

12:00 – 12:30pm Systems Biology Grantees Meeting - Concurrent Session (Room A)

Pankaj Qasba (NHLBI)

12:30-1:30pm Lunch on your own (cafeteria in building), View Posters (Room D)

1:30 – 2:45pm Theme 3 Presentations: Similarities/differences in MSM for various biological systems (nervous, cardiovascular, immunology etc.)

IMAG Moderators: Albert Lee (NHLBI), German Cavelier (NIMH)

1:30-1:45pm

Mike King - Multiscale model of platelet tethering and adhesion: similarities with the leukocyte adhesion cascade

1:45-2:00pm

Denise Kirschner - The importance of multi-scale and multi-organ approaches to understand host-pathogen dynamics in TB

2:00-2:15pm

Saleet Jafri - Calcium signaling in heart: Multi-scale modeling with instabilities

2:15-2:30pm

Russell O'Connor - A prototype neuromechanical model of airway defensive reflexes

2:30-2:45pm

Merryn Tawhai - A multi-scale model to study airway hyper-responsiveness

2:45 – 3:15pm Theme 3 Discussion - Ravi Radhakrishnan, Bill Lytton, Vasilis Marmarelis, Mounya Elhilali

3:15 – 5:00pm Poster Session, Refreshments (Room D)

5:00pm Meeting Adjourn