The participating Institutes and Centers (ICs) are inviting applications to expand existing awards in these ICs that are not currently focused on Alzheimer’s disease (AD) and its related dementias (ADRD) to allow them to develop a focus on AD/ADRD. Active awards with project end dates in FY 2019 or later are eligible. The award may not be in terminal no cost extension or going into no cost extension in FY2018. As administrative supplements the work proposed needs to be within the scope of the research or training that is already supported. Center awards and resource awards are most likely to be able to justify these supplements as they tend to have a broad content scope. Some research grants will also qualify if the current research is on a related topic (such as cognitive decline in aging, caregiving, or health disparities). Other possible topics include research on the biology of neurodegeneration, on genetics, or imaging, or on pain perception and communication. Topics also include possible connections to existing conditions that are being studied: such as links to cardiovascular or other diseases, on common pathways of degeneration, on sex and gender influences in incidence, or on previously unidentified risk factors. Also work that focuses on advances in methodology, or machine learning or other modeling, or on biostatistical tools that have application to research on Alzheimer’s and its related dementias may be appropriate. NIA has developed a website that shows abstracts (from Reporter) of a sample of awards that are recognized as pursuing AD/ADRD research under current guidelines. The site also includes a description of the categories of research NIH currently identifies as Alzheimer's disease or Alzheimer's disease-related dementias. As part of the application investigators should submit an abstract of the proposed research that shows the relevance to AD/ADRD. The work may include pilot projects, or resource development. Investigators should submit applications as responses to the parent active administrative supplement PA: https://grants.nih.gov/grants/guide/pa-files/PA-18-591.html Individual requests can be no more than $250,000 in direct costs exclusive of Facilities and Administrative costs on sub-contracts (except see the information from NHGRI below). Requests may be for one year of support only.  Though supplement requests are not limited to one per parent grant, we will consider substantial additional funding to an award as beyond its scope. Also, before submitting a supplement request, principal investigators are strongly encouraged to contact their program officers in the Institute, Center or Office supporting their award to discuss whether the proposed supplement is within its scope.

Requests must be received by June 8 for funding in FY 2018.