The purpose of the Funding Opportunity Announcement (FOA) is to support research that employs systems biology approaches to human pathogens.  The approach will generate and integrate large datasets into models that guide in vitro, in vivo and clinical studies, with the goals of predicting disease severity, predicting responses to vaccines and therapeutics, and identifying candidate targets for interventions.  

There is a minimum requirement of 2 research projects with a maximum of 3 research projects.  In addition, an ‘Overall’ component that provides an overview of the entire program is required.  The following cores are required: Administrative Core (maximum of 1); Data Management and Bioinformatics Core (maximum of 1); Technology Core (maximum of 1); Modeling Core (maximum of 1).