IMAG/MSM WG Multiscale Modeling and Viral Pandemics Zoom

To join the meeting:
https://iu.zoom.us/meeting/register/tZYqd-2srD8tGtCXDem4Cka08rBz5fDW0EQR

Please feel free to forward this invitation to anyone you think would be interested.

Thursday December 12 at 3:00PM (EST)

The schedule for this week consists of one presentation:

Valeriu Damian, Senior director System Modelling and Translational Biology at GSK, will discuss: Digital Twin approaches in Quantitative Systems Pharmacology.
Originally developed in the manufacturing industry, digital twin concepts have emerged as a transformative tool in quantitative systems pharmacology (QSP). This talk explores how digital twins can estimate population responses in clinical trials and enable personalized treatments, particularly for rare diseases and severe conditions where large-scale trials are impractical. We will compare digital twin methodologies with traditional virtual population algorithms in QSP modeling, highlighting how these approaches integrate patient-specific clinical data, and treatment history to build individualized models. Using a pediatric bone marrow transplant model as an example, we will discuss the challenges of balancing model accuracy with timely utility, emphasizing the importance of actionable predictions within the clinical decision-making window.