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  5. HighlyIntHuman_wIntervention - Differences between model and literature

HighlyIntHuman_wIntervention - Differences between model and literature

  • No aortic valve resistance listed in Lu et al. (2001). We used a low valve resistance (tricuspid) for this parameter. Note: Tricuspid resistance listed as "Rta" in Glossary of publication is not listed in Table 4.
  • Using the values listed in Table 5 of Lu et al. (2001), we plotted Pvc vs. Vvc after running the syscirc model for several cardiac cycles. There was a discontinuity in this graph when Vvc = Vo (Vena cava volume = unstressed Vena cava volume). The curve above Vo began at a lower value than the end of the curve below Vo. We therefore replaced the D1 parameter in the equation for distended Vena cava volume with the expression for undistended Vena cava volume solved at Vo.
  • Value of baroreceptor parameter "a" not given an explicit value in either Lu et al. (2001) or Kezdi and Geller (1967). A value of 0.001 is assumed as the default.
  • We ignore the 1/2 in the Lu et al. (2001) equation 10 because the 1/2 does not appear in the Chung et al. (1997) ventricular actiavtion function (equation A7).
  • Lu et al. (2001) use a previously published heart model (Chung et al. 1997). Their unstressed end-diastolic and end-systolic ventricular (and possibly atrial) volumes are static parameters, while ours can vary with the contraction and relaxation of the heart chambers.
  • Lu et al. (2201) do not include an interstitial compartment in their gas exchange model
  • We do not include the spatial component requiring partial differential equations that Lu et al. (2001) use in their gas exchange model.
  • Pulmonary capillary resistance is kept constant. It varies with alveolar volume in Lu et al. (2001)

Model development and archiving support at https://www.imagwiki.nibib.nih.gov/physiome provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.