A closed loop cardiopulmonary model composed of a four-chamber varying-elastance heart, a pericardium, a systemic circulation, a pulmonary circulation, a coronary circulation, and baroreceptors.

Description

 The model simulates physiological features such as the arterial blood pressure waveform,
 end-diastolic left ventricular volume, and coronary capillary flow.

 This model is a reduced form of the Highly-integrated_human_with_interventions model. 
 The code for simulation of interventions and injuries (aka Physiological Changes), 
 peripheral chemoreceptors, blood gas handling, gas exchange, and airway mechanics has 
 been removed from the parent model to create the present system.

 The JSim project file allows the user to simulate certain interventions by changing 
 model parameters in the “Inputs” page. For example, the parameter for pulmonary valve 
 resistance (Rpuv) can be increased to simulate pulmonary valve stenosis. 

 This model is a reduced form of the Highly-integrated_human_with_interventions model, 
 which has been partially validated. The code for simulation of interventions and 
 injuries (aka Physiological Changes), peripheral chemoreceptors, blood gas handling, 
 gas exchange and airway mechanics has been removed from the parent model to create the 
 present system. 	

Equations

The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.