Neuronal mechanisms of human episodic memory

Investigator Names  Ueli Rutishauser, Adam Mamelak, Taufik Valiante, William Anderson, Michael Miller, John Thompson
Institutions Cedars-Sinai Medical Center, University of Colorado Denver, John's Hopkins University, University of California Santa Barbara, University of Toronto
Grant support: NIH BRAIN, U01NS117839 & U01NS103792
Performance period  2017-2020, 2020-2025

 

Goal: To advance the mechanistic understanding of human memory. We test key circuit-based hypotheses by recording single-neurons from the medial temporal lobe and frontal areas in humans who are forming, declaring, and describing their memories. 

An overview of methods used by collaborators. In the image, a comic rendering of a subject is watching either a series of images or movies, with LFP spiking data and behavioral data being recorded.

Study population and setting:

  • Participants are epilepsy patients undergoing invasive monitoring with depth electrodes for evaluation for potential resective surgery.
  • Recording systems used are Neuralynx Inc. ATLAS and Blackrock Inc. Neuroport. 

Data generated:

  • Single-neuron recordings, local field potentials, eye tracking data, and behavior. Data management and exchange utilizes the Neurodata Without Borders format. We use the DANDI archive for the release of datasets. 

Resources:

Public Datasets:

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