1.5 - Addressing Gaps and Challenges to Successful BDT Implementation - Part 1

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What are the other components of the NASEM Digital Twin?

Charge to Speakers:

Consider the expert topics for each presentation. How can BDT developers incorporate these tools, resources and mindset?

What are some major components:

  • Fit-for-Purpose BDT
  • Verification, Validation, and Uncertainty Quantification (VVUQ)
  • Physical Assets/Data Collection/Sensors
  • Mathematical and Statistical Foundations for BDT
  • Virtual to Physical Control Algorithms/Expert in the Loop
  • Ethical, Security Issues
  • Team Science, Governance

Part 1: Technical Components

Each speaker will present a 10-minute talk, followed by 5 minutes for questions

Reinhard Laubenbacher: Embedded mathematical, statistical, and computational algorithms for VVUQ, virtual assets and data/knowledge systems

Julian Goldman: Real-time measurements for closed loop control to address systems of systems interoperability for regulated BDTs

Part 2: Social Components

Each speaker will present a 10-minute talk, followed by 5 minutes for questions

Michelle Bennett: Team Science, governance to consider sustainability

Barbara Evans: Embedding a culture of ethical inquiry, privacy, and consent for trustworthy BDT

Speaker Bios:

Reinhard Laubenbacher

Julian Goldman

Michelle Bennett

Barbara Evans

Moderator Bio:

Gary An

Materials:

Presentations:

Comment

Your name
Tracy Salseth
Comment

Great lectures, especially Dr. Julian Goldman, for an insightful presentation on the SaAMS Collaborative Community and ACLIVA. The emphasis on shared safety standards and pre-competitive collaboration is a brilliant approach to tackling key challenges in medical device innovation. Excited to see how this initiative will shape the future of anesthesia and patient care.

Submitted by tracy.salseth on Mon, 09/30/2024 - 13:40

Your name
Raj Vadigepalli
Comment

Who owns the DT? Can the individual ask that their DT be disposed off after the purpose was achieved? How to regulate that?

Submitted by Anonymous (not verified) on Mon, 09/30/2024 - 14:01

Your name
Raj Vadigepalli
Comment

Who owns the DT? or, at least have control over what happens to the DT after the purpose is achieved? Should the patient have a say in whether it is automatically archived or disposed off?

Are current laws on regulating patient records and HIPAA sufficient to deal with this?

Submitted by raj_vadigepalli on Mon, 09/30/2024 - 14:02

Your name
Michelle Gee
Comment

What do companies currently do with all of the data collected through fitness trackers? This is the precedent that comes to mind

Your name
James Hu
Comment

Manufactures are very protective and conservative. They are interested in only having their devices work together in their own ecosystem of devices.

How do you think is the best way to incentivize and/or enforce interoperability for between manufacturers?

Submitted by James Hu (not verified) on Mon, 09/30/2024 - 14:07

Your name
Tracy Salseth
Comment

As digital twin technology advances, particularly in predictive modeling for mental health and Substance Use Disorder (SUD), how can we rigorously safeguard patient autonomy, privacy, and prevent algorithmic bias, especially considering the potential implications for individuals facing stigma or legal consequences?

Submitted by Anonymous (not verified) on Mon, 09/30/2024 - 14:08

Your name
Raj Vadigepalli
Comment

It gets even more tricky.

If Apple Watch builds a digital twin of my activity, who owns that model? who should have a say in using/disposing it?

This would be outside of HIPAA? Now what?

Submitted by raj_vadigepalli on Mon, 09/30/2024 - 14:11

Your name
Michelle Gee
Comment

Wonderful panel discussion. Question for Dr. Bennett. I thought it was interesting that teams are more likely to disintegrate with more experts. Does the way that we train our experts have to do with the teams disintegrating or is it more a "curse of knowledge"?

Submitted by Anonymous (not verified) on Mon, 09/30/2024 - 14:18

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