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Lung Modeling Tutorial

-- Mechanics

-- Ventilation crontrol

-- Alveolus-capillary gas exchange

-- Capillary-tissue exchange

-- Gas buffers

-- Airway-wall exchange

-- Air-body exchange

Mechanics

-- One alveolus lung

-- One alveolus lung driven by interpleural pressure

-- One alveolus compliant lung with inhaled gas

-- 2 Compartment lung

-- Lutchen 1982

-- Bronchi- Bronchiole -Alveoli

-- Bronchiole-2 Alveoli

-- Four compartment lung

-- Bifurcating Airway

-- Bifurcating Bronchiole

-- Surfactant effects

-- Weibel rigid 4 generation

-- Weibel compliant 4 generation lung

-- Normal ventilation

-- Vital capacity

-- Airway obstruction

-- Alveolar collapse

-- Pleural pressure

-- FEV

-- Pneumo thorax

-- Athanasiades 2000

-- Lung Exchange (O2<->CO2)

Ventilation crontrol

-- Breathing CO (ventilation response to CO inhalation)

-- Chemoreceptor

-- Breathing CO2

-- Duffin Chemoreceptor

Alveolus-capillary gas exchange

-- Alveolar capillary exchange (Two tank exchange)

-- Alveolar capillary exchange with simple binding in capillary

-- Four tank exchange

-- Alveolar capillary gradients

-- Homogenous Air-Blood exchange: Hlastala 1972

-- Lu 2001 (air-blood gas exch)

Capillary-tissue exchange

-- Two Compartment with flow

-- Two Compartment with buffer

-- BTEX 20

-- BTEX 30

-- BTEX 40

-- CTEX 20

-- Sangren-Shepard 1953

-- BTEX of O2, CO2, HCO3, and H+

-- GENTEX (general whole organ)

Gas buffers

-- MbO2

-- HbO2 Hill

-- HbO2 Adair

-- HbO2 Severinghaus 1979

-- Blood O2

-- Hb with independent binding sites

-- Hb with cooperative binding

-- HbCO2

-- HbO2 binding w/ CO2, H+, DPG, and temp

-- BTEX of O2, CO2, HCO3, and H+

Airway-wall exchange

-- Soluble gas transport in the alveoli: Kumagai 2000

-- Ethanol Anderson

-- Bronchiole Capillary exchange

Air-body exchange

-- Styrene inhalation

-- Four tank gas exchange (2 comp lung and 2 comp body)

-- CV Respiratory

Model development and archiving support at https://www.imagwiki.nibib.nih.gov/physiome provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.