Single substrate single product reversible enzymatic reaction with parameters for phospho-gluco isomerase in erythrocytes (Ref 1)
Description
Single substrate single product reversible enzymatic reaction with parameters for phospho-gluco isomerase in erythrocytes (Ref 1). Follows the Haldane constraint that the reaction is reversible and there is an equilibrium ratio of concentrations given by Kappa = [P]/[S] at equil = k1*k2/(k_1*k_2), Eq 10-29 in Bassingthwaighte's Chapter 10 on Metabolism.(Ref 2)
Equations
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Mulquiney PJ and Kuchel PW. Model of 2,3-bisphosphoglycerate metabolism in the human erythrocyte based on detailed enzyme kinetic equations: equations and parameter refinement. Biochem J 342: 581-596, 1999 Bassingthwaighte, JB, Ch 10 Enzymes and Metabolic Reactions in "Transport in Biological Systems" Springer ( in preparation ) RELATED MODELS: #130 One_Enzyme_Reversible.proj
Please cite https://www.imagwiki.nibib.nih.gov/physiome in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.
Model development and archiving support at https://www.imagwiki.nibib.nih.gov/physiome provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.