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Sachse2008_Fibroblast

Model number
0140

  

A model of fibroblast electophysiology developed by Sachse et al. 2008. JSim v1.1

Description

 This model of fibroblast electrophysiology, based on data from whole-cell patch clamp and
 polymerase chain reaction (PCR) studies, is taken from the paper by Sachse et al. (Ann Biomed Eng, 2008). 
 An inward rectifying current, IKir, and a time and voltage dependent outward current, IShkr, are the
 main determinants of the fibroblast's voltage-current relationship. The model additionally includes 
 an unspecified background current, Ib, and a stimulus current, Istim. The inward current 
 is modeled here as nearly instantaneous and is modulated by the external K+ concentration. 
 Measurements of the outward current on the other hand show delayed rectifier and slow 
 inactivation properties. Therefore a Markovian model of delayed rectifier currents is used. 
 The background current was described as in previous ohmic models of kidney and cardiac fibroblasts. 
 The set of equations used in this model are given below.

fig 1

Equations

e0

Constants of fibroblast model:

table 1

Physical constants:

table 2

Initial values of fibroblast model for [K+]o=5 mM:

table 3

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References
 Sachse FB, Moreno A, Abildskov JA.; Electrophysiological modeling of fibroblasts and their interaction 
 with myocytes. Annals of Biomedical Engineering 36(1): 41-56, 2008.
Related Models
Key terms
Fibroblast
Publication
Cell physiology
electrophysiology
voltage-current
Acknowledgements

Please cite https://www.imagwiki.nibib.nih.gov/physiome in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

Model development and archiving support at https://www.imagwiki.nibib.nih.gov/physiome provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.