A model for a physiological based description of the inhalation pharmacokinetics of styrene in rats and humans based on the work of J.C. Ramsey and M.E. Andersen [(1984). Toxicol Appl Pharm. 73(1), 159-175.], developed by Neil Geisler (2006) as a final project for BIOEN 589, University of Washington.

Description

   This model presents a the phramacokinetics of styrene inhalation
 in rats and humans based on the 1984 paper by Ramsey and Andersen paper     
 (reference below). Four body compartments are considered: richly perfused tissue  
 (highly perfused), muscle (moderately perfused), fat (slowly perfused), and 
 liver, which includes metabolic consumption of styrene. Styrene is inhaled at a 
 given concentration for a specified time, then normal ventilation continues. 
 Parameters for rats and humans are included, and are listed in the code below 
 along with parameters for mice as provided in the paper.  Two plot pages, one 
 for rats and one for humans, are given to reflect identical traces plotted in 
 the paper. 

Equations

Styrene Ventilation:

Styrene uptake, release, and metabolism in the tissue:

The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.