Surfactant | Interagency Modeling and Analysis Group

Model number

0197

Surfactant effect on single bubble dynamics: This models the dynamic adsorption, desorption, and squeeze-out phenomena of surfactant

Description

 This models the dynamic adsorption, desorption, and squeeze-out 
phenomena of an exogenous pulmonary surfactant (surfactant TA) 
solution surrounding an oscillating bubble.
 The influence of the alveolar surface tension on the concentration
of the surfactant lining the alveolus can be simulated by this 
model describing the adsorption/desorption kinetics of a surfactant
on a bubble and the change in surface tension generated. The volume
of the bubble is driven in a sinusoidal manner.

fig 1

Equations

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References

 Otis et al.; Dynamic surface tension of surfactant TA: 
experiments and theory. J Appl Physiol 77:2681-2688, 1994.

 Y.C. Fung; Biomechanics: Mechanical Properties of Living Tissues,
Second Edition, Springer-Verlag, New York, 1993, pp16-17

Related Models

None.

Key terms

lung alveolus

surface tension

bubble dynamics

surfactant TA concentration

lung compliance

functional residual volume

pulmonary mechanics

intrapleural pressure

lung elasticity

Respiratory mechanics

Airway mecahnics

Acknowledgements

Please cite https://www.imagwiki.nibib.nih.gov/physiome in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

Model development and archiving support at https://www.imagwiki.nibib.nih.gov/physiome provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.