I would argue that the process of scientific discovery is inefficient and therefore not cost effective and hence only able to exploit a fraction of what needs to be explored. In a small way, we are in the early stages of a project that tries to address these shortcomings through community enablement. The 3D Virtual Cell Project seeks to establish the community and infrastructure to accelerate interdisciplinary science through the in silico modeling and simulation of the action of a living cell. Building community is not easy and requires building trust and providing reward in a shared space; efficient modeling requires new software approaches. The end result should be the accurate prediction of cellular function under a variety of environmental conditions delivered through new modes of dissemination and learning. I will discuss progress to date and hope to engage you in a discussion of the broader issues.