Theme 3- Goal and Charge to Speakers

Returm to 2015 MSM Consortium Agenda

Theme 3: Multiscale Modeling for Optimal Disease Diagnosis/Treatment Applications

Goal: Share and discuss methods for developing and incorporating multiscale modeling into the advancement of disease diagnosis/treatment models to advance clinical therapies.

Objectives: The speakers will address the Theme 3 Goal with the following four objectives:

Identify strategies required to successfully navigate barriers to incorporation of multiscale models into clinical diagnostic/therapeutic applications
Describe and illustrate key examples of computational methods used to bridge multiple scales in development of the models
Provide insight regarding the adoption of valid computational models by medical practitioners
Describe challenges that need to be pursued

Charge to the speakers, Theme 3:

In your field, what is the status of incorporating MSM models into clinical decision support?
What are the challenges that need to be overcome to facilitate and accelerate implementation?

September 9, 2015

Theme 3

11:00 am – 12:30pm: Multiscale Modeling for Optimal Disease Diagnosis/Treatment Applications

Moderator: David Eckmann

11:00-11:10am Maciej Swat - Virtual-tissue computer simulations

11:10-11:20am Scott L. Diamond - Coarse graining data-driven cellular models in multiscale simulations

11:20-11:30am Gary An - The meaning of parameter space as related to clinical populations: lessons from the simulation of 80 million sepsis patients

11:30-11:40am Feilim Mac Gabhann - From proteins, viruses and cells to patient 9opulations: simulations of potential HIV cures

11:40-11:50am Jean-Marie C Bouteiller - Multiscale Modeling: A Valuable Asset for Therapeutics Development

11:50-12:00pm Don Bolser - Value of computational modeling in understanding human pulmonary defensive reflexes

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