Contributors
Penelope A Morel MD. Department of Immunology, University of Pittsburgh. Title: The immune response to SARS-CoV-2: Friend or Foe?
Katherine L. Morse, IEEE Fellow, Principal Professional Staff, JHU/APL. Title: Standards and standards development.
Katherine L. Morse, IEEE Fellow, Principal Professional Staff, JHU/APL. Title: Standards and standards development.
Institution/ Affiliation
Penelope A Morel MD. Department of Immunology, University of Pittsburgh.
Katherine L. Morse, IEEE Fellow, Principal Professional Staff, JHU/APL.
Katherine L. Morse, IEEE Fellow, Principal Professional Staff, JHU/APL.
Presentation Details (date, conference, etc.)
April 29, 2021, IMAG/MSM WG on Multiscale Modeling and Viral Pandemics
- Penelope Morel Slides, Video, Title: The immune response to SARS-CoV-2: Friend or Foe? Abstract: The novel SARS-CoV-2 coronavirus is responsible for worldwide pandemic that has infected over 145 million people resulting in over 3 million deaths. The immune response to SARS-CoV-2 involves both innate and adaptive responses and it appears that the timing and magnitude of these responses are important factors in determining the outcome of the infection. For the vast majority of those infected by SARS-CovV-2 develop classic anti-viral immunity leading to a mild clinical course. The picture is very different for the 10% of infected individuals who develop serious disease, which can lead to respiratory failure, multi-organ failure and death. This is associated with a hyperinflammatory state, with high levels of circulating cytokines, and a failure of the adaptive immune response. The development and distribution of effective vaccines is beginning to have an impact on infections and disease rates. However, questions remain unanswered concerning the longevity of immunity, the impact of new viral variants and the emergence of long-hauler disease. In this talk we will examine how the timing and magnitude of the immune response to SARS-CoV-2 impacts disease outcomes, and how modeling may provide new insights on disease and therapeutics.
- Katherine L. Morse Slides, Video, Title: Standards and standards development. Abstract:
- Existing relevant SISO standards and standards development activities: DSEEP, HLA, FEAT, Simulation Interoperability Readiness Levels (SIRL);
- How standards processes work, using SISO as an example;
- SISO standards and standards development activities that aren’t germane to biomed, but fit in the same niche in a standards portfolio where they have gaps as a way of illustrating how these gaps can and are filled.
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