NOTE: XSIM is NO Longer supported!

XSIM Interface Tour

We have provided a tutorial and tour through XSIM that demonstrates many of its capabilities (video clips are provided for MS Windows users; an X server is not required.

Blood-Tissue Exchange Models

Single-element models

simpipe

Flow through a pipe.

micmen

A simple model for Michaelis-Menten reaction.

enzmem

Two enzymes in vesicle.

FacTransport

A set of nonlinear transmembrane transporters (tutorial available).

Single capillary-tissue unit

comp2ode

A two-compartment blood-tissue exchange model.

btex20

A two-region, distributed blood-tissue exchange model.

btex40

A four-region, distributed blood-tissue exchange model.

Whole-organ models

mmid4

A multi-path, multi-indicator, four-region organ model (tutorial available).

msid4

A multi-path, multi-species, four-region organ model.

gentex

A multi-path, multi-species, five-region organ model with nonlinear transmembrane transport, nonlinear reactions and time-varying blood flow and volume (tutorial available).

compos

A model of coupled solute-solvent exchange between two compartments.

osmotic

A model of solute and water fluxes in a whole organ.

Whole-body models

simvol

Multi-organ recirculating system with shunt.

body

A whole-body recirculation model.

Cellular Models

Action potential models

hodhux

Hodgkin-Huxley model for membrane conductance.

MLRd

Modified Luo-Rudy dynamic model of the guinea pig cardiac ventricular action potential in a single cell.

ito1

An ion channel model recently developed by J. L. Greenstein to study the "Role of the Calcium-Independent Transient Outward Current I_to1 in Shaping Action-Potential Morphology and Duration" (Circ Res. 87:1026-1033, 2000).

wrj3

Action potential model for canine ventricular cell (Winslow-Rice-Jafri model version 3) that incoporated the above I_to1 model developed by J. L. Greenstein el al.

jbAP

Modification of wrj3 by A. Michailova and A. D. McCulloch.

Metabolic models

Demo Models

demo

Decaying sine, cosine, and tangent waves.

BTEX

A demo to illustrate the theory and method of the axially-distributed blood-tissue exchange model (video clips for MS Windows users).

Model development and archiving support at https://www.imagwiki.nibib.nih.gov/physiome provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.