JSim Consolidated Model Database
Showing 101 - 150 of 433 models found. [New Search]
NSR0101 (in NSR archive): EC_Silva_AJP2007
A mathematical model of plasma membrane electrophysiology and calcium dynamics in vascular endothelial cells.
A mathematical model of plasma membrane electrophysiology and calcium dynamics in vascular endothelial cells.
- Key terms: calcium dynamics, gap junctions, ion channels, microcirculation, Endothelium, norepinephrine, electrophysiology, membrane potential, vascular tone regulation, calcium influx pathway(s), plasma membrane Ca2+-ATPase
- EC_Silva_AJP2007
NSR0102 (in NSR archive): CortisolSecrete
Two compartment model with feedback control of precursor (pregnenolone) to cortisol and its adrenal secretion.
Two compartment model with feedback control of precursor (pregnenolone) to cortisol and its adrenal secretion.
- Key terms: compartment, tutorial, exchange, multiple compartments, flux, steady state, reaction, endocrine, ACTH, adrenal, cortisone, cortisol, control system, secretion, feedback, step response, mathematical model, analog computer
- CortisolSecrete
NSR0103 (in NSR archive): Comp4ICG
Four-compartment whole body model with recirculation: repeated injections and first order hepatic clearance of Indocyanine Green dye.
Four-compartment whole body model with recirculation: repeated injections and first order hepatic clearance of Indocyanine Green dye.
- Key terms: Compartment, compartmental, flow and exchange, mixing chamber, Data, permeability, PS/F, washout, organ, multi-organ, Comp2x2Recirc, Monte Carlo
- Comp4ICG
NSR0105 (in NSR archive): Vboltzmann
Model of Boltzmann gated channel conductance vs. transmembrane voltage for any ion. Valence and # of gating charges are variable.
Model of Boltzmann gated channel conductance vs. transmembrane voltage for any ion. Valence and # of gating charges are variable.
- Key terms: Channel, Nernst potential, ionic current, gating current, conformational state, Tutorial, boltzmann, ion valence, electrophysiology
- Vboltzmann
NSR0106 (in NSR archive): VboltzmannLagged
Model of Boltzmann gated channel conductance vs. transmembrane voltage for any ion. Conductance change has fixed timelag, tau.
Model of Boltzmann gated channel conductance vs. transmembrane voltage for any ion. Conductance change has fixed timelag, tau.
- Key terms: Channel, Nernst potential, ionic current, gating current, conformational state, Tutorial, membrane potential, Boltzmann, electrophysiology
- VboltzmannLagged
NSR0107 (in NSR archive): GoldmanNaKPump
Model of transmembrane resting potential due to concentration differences in K, Na, and Ca across a membrane with constant conductance for each ion.
Model of transmembrane resting potential due to concentration differences in K, Na, and Ca across a membrane with constant conductance for each ion.
- Key terms: Channel Nernst potential, ionic current, resting membrane potential, Tutorial, Electrophysiology
- GoldmanNaKPump
NSR0108 (in NSR archive): GoldmanNaKPump2
Model of transmembrane resting potential due to concentration differences in K, Na, and Ca with constant conductances for the ions, plus accounting for the NaKPump current using an implicit calculation of EQ.10.4 from Sperelakis (1979).
Model of transmembrane resting potential due to concentration differences in K, Na, and Ca with constant conductances for the ions, plus accounting for the NaKPump current using an implicit calculation of EQ.10.4 from Sperelakis (1979).
- Key terms: Channel Nernst potential, ionic current, resting membrane potential, Tutorial, electrophysiology
- GoldmanNaKPump2
NSR0110 (in NSR archive): Comp1Flow.TracerBind
Tracer and Mother solute flow past a binding site. Equilibrium upset by an added pulse of mother solute, dislodging tracer.
Tracer and Mother solute flow past a binding site. Equilibrium upset by an added pulse of mother solute, dislodging tracer.
- Key terms: Tracer, mother, analyte binding to fixed ligand, dissociation curves, Tutorial, competitive binding, dissociation and association rates, equilibrium, radioactive marker, compartment
- Comp1Flow.TracerBind
NSR0111 (in NSR archive): Comp2_LignocainePassage
A model of the first pass passage of drugs from i.v. injection site to the heart based on the work of Upton RN, 1996. Models the kinetics and dynamics of induction of anaesthesia (lignocaine) in sheep.
A model of the first pass passage of drugs from i.v. injection site to the heart based on the work of Upton RN, 1996. Models the kinetics and dynamics of induction of anaesthesia (lignocaine) in sheep.
- Key terms: pharmacokinetics, models, heart, myocardium, metabolism, anaesthetics, lignocaine, sheep, Data, Transport physiology, Compartmental, Comp2, Publication
- Comp2_LignocainePassage
NSR0112 (in NSR archive): Transp2sol.Comp2.PS
Models a two compartment, 2 solute, T1-T2 (facilitated 6-state transporter with effective PS calculation. Directly related to model Transp2sol.Comp2 (model #10).
Models a two compartment, 2 solute, T1-T2 (facilitated 6-state transporter with effective PS calculation. Directly related to model Transp2sol.Comp2 (model #10).
- Key terms: Two solutes, competing solutes, enzymatic reaction, transmembrane flip, countertransporter, six state transporter, tutorial, Transp2sol, two compartment, effective PS
- Transp2sol.Comp2.PS
NSR0113 (in NSR archive): Vessel_Mechanics
This model describes how a microvessel responds to changes in intraluminal pressure in the steady state. This change in vessel diameter to pressure is known as the myogenic response.
This model describes how a microvessel responds to changes in intraluminal pressure in the steady state. This change in vessel diameter to pressure is known as the myogenic response.
- Key terms: Data, intraluminal, microvessel, myogenic response, stress strain, tension, vascular smooth muscle, Vessel mechanics
- Vessel_Mechanics
NSR0119 (in NSR archive): Competitive_Inhibition
This model shows the case of an enzyme facilitating the formation of a product from a substrate but an inhibitor exists which also can bind to the enzyme rendering it ineffective.
This model shows the case of an enzyme facilitating the formation of a product from a substrate but an inhibitor exists which also can bind to the enzyme rendering it ineffective.
- Key terms: Transport Physiology, Enzymatic Reaction, Enzyme, Inhibitor, Michaelis-Menten Kinetics, Reaction Rates
- Competitive_Inhibition
NSR0120 (in NSR archive): Comp_four_gen_weibel_lung
This model represents four generations of the bipodial human lung or the Weibel lung. The lengths and diameter of the airways are based on the Weibel lung geomtery. The airways are assumed compliant.
This model represents four generations of the bipodial human lung or the Weibel lung. The lengths and diameter of the airways are based on the Weibel lung geomtery. The airways are assumed compliant.
- Key terms: Compliant lung, Weibel model, Human lung model, Tutorial, Respiratory System, Respiratory Mechanics, Airway
- Comp_four_gen_weibel_lung
NSR0122 (in NSR archive): Compliant_bifurcating_airway
This model represents a bifurcating compliant airway that could be used as a building block for constructing a network of airways. You could use the model to simulate flow in rigid airway bifurcation.
This model represents a bifurcating compliant airway that could be used as a building block for constructing a network of airways. You could use the model to simulate flow in rigid airway bifurcation.
- Key terms: Airway, Compliant airway, Bifurcating airway, Weibel, Lung, Respiratory system, respiratory mechanics
- Compliant_bifurcating_airway
NSR0123 (in NSR archive): Compliant_bifurcating_bronchiole
This model represents a bifurcating compliant bronchiole that could be used as a building block for constructing a network of bronchi.
This model represents a bifurcating compliant bronchiole that could be used as a building block for constructing a network of bronchi.
- Key terms: Bronchiole, Bronchiolus, Compliant bronchiole, Compliant bronchiolus, Bifurcating bronchiole, Respiratory system, respiratory mechanics, airway
- Compliant_bifurcating_bronchiole
NSR0124 (in NSR archive): Compliant_bifurcating_bronchiole_compliant_alveoli
This model represents a bifurcating compliant bronchiole with two compliant alveoli.
This model represents a bifurcating compliant bronchiole with two compliant alveoli.
- Key terms: Compliant bronchiole, Compliant alveoli, Compliant alveolus, Bronchiole, Alveolus, Respiratory system, respiratory mechanics, airway
- Compliant_bifurcating_bronchiole_compliant_alveoli
NSR0125 (in NSR archive): Compliant_bronchiole_compliant_alveolus
This model represents a compliant bronchiole with a compliant alveolar sac. The driving force for this model is a pressure gradient which represents the difference in the alveolar and the pleural pressures.
This model represents a compliant bronchiole with a compliant alveolar sac. The driving force for this model is a pressure gradient which represents the difference in the alveolar and the pleural pressures.
- Key terms: Compliant Bronchiole, Bronchiolus, Alveolus, Alveolar sac, Respiratory system, respiratory mechanics, airway
- Compliant_bronchiole_compliant_alveolus
NSR0126 (in NSR archive): Kuikka1986_MPBTEX20
Two region multi-path BTEX model. Used to model D-glucose uptake in the heart. Model fit to Kuikka et al. 1986 rabbit heart data.
Two region multi-path BTEX model. Used to model D-glucose uptake in the heart. Model fit to Kuikka et al. 1986 rabbit heart data.
- Key terms: BTEX20, coronary transport function, L-glucose, rabbits, dogs, PDE, myocardial transsarcolemmal flux, Data, permeability-surface area product, ISF, MPC, capillary, multi-path, flow heterogeneity, albumin, D-glucose, Data
- Kuikka1986_MPBTEX20
NSR0127 (in NSR archive): Concen_Polarization
When flow of solute in a solution under pressure is retarded so that its flux across a membrane is slower than the solvent flux, it accumulates on the upstream side of the membrane. This "polarization" retards solvent flow osmotically.
When flow of solute in a solution under pressure is retarded so that its flux across a membrane is slower than the solvent flux, it accumulates on the upstream side of the membrane. This "polarization" retards solvent flow osmotically.
- Key terms: Osmotic pressure, Polarization, Solute, Solvent, Filtration, Membrane, Transport Phsyiology, Diffusion
- Concen_Polarization
NSR0128 (in NSR archive): Zinemanas1994_CoronaryCirc
A lumped parameter model of the coronary circulation. A resistive-compliant network is used to simulate the following circulatory compartments: epicardial arteries, large coronary arteries, small coronary arteries, coronary capillaries, small coronary veins, large coronary veins, and epicardial veins.
A lumped parameter model of the coronary circulation. A resistive-compliant network is used to simulate the following circulatory compartments: epicardial arteries, large coronary arteries, small coronary arteries, coronary capillaries, small coronary veins, large coronary veins, and epicardial veins.
- Key terms: coronaries, coronary, circulation, intramyocardial pressure, cardiovascular system, circulatory networks, Zinemanas, epicardial, endocardial, lumped parameter, Publication
- Zinemanas1994_CoronaryCirc
NSR0130 (in NSR archive): One_Enzyme_Reversible
First-order reversible enzymatic reaction with binding of either substrate or product to enzyme and allows thermodynamic equilibrium.
First-order reversible enzymatic reaction with binding of either substrate or product to enzyme and allows thermodynamic equilibrium.
- Key terms: Transport Physiology, Chemical Reaction Enzymes, Enzymatic Reaction, Single Enzyme, Reversible, Michaelis-Menten Kinetics, Briggs-Haldane Kinetics RELATED MODELS: PGIsomerase
- One_Enzyme_Reversible
NSR0131 (in NSR archive): One_Enzyme_Sequestered
This model simulates a single enzyme reaction which occurs inside a vesicle where the substrate and product diffuse across the vesicle boundary on each end of the reaction.
This model simulates a single enzyme reaction which occurs inside a vesicle where the substrate and product diffuse across the vesicle boundary on each end of the reaction.
- Key terms: Transport Physiology, Chemical Reaction Enzymes, Enzymatic Reactions, Sequestered, Single Enzyme, Reversible, Michaelis-Menten Kinetics, Vesicle, Cell Membrane, Lysosome
- One_Enzyme_Sequestered
NSR0133 (in NSR archive): Two_Enzyme_Sequestered
This model represents a two enzyme reversible reaction where the two enzymes are sequestered inside a vesicle and substrate and product are allowed to diffuse across the vesicle boundary.
This model represents a two enzyme reversible reaction where the two enzymes are sequestered inside a vesicle and substrate and product are allowed to diffuse across the vesicle boundary.
- Key terms: Sequestered, Two Enzyme, Vesicle, Enzyme, Reversible, enzymatic reaction
- Two_Enzyme_Sequestered
NSR0134 (in NSR archive): Exchange_O2_CO2_HCO3_and_H
Four region, distributed model for the O2-CO2 transport, exchange and metabolism.
Four region, distributed model for the O2-CO2 transport, exchange and metabolism.
- Key terms: Rheology, Axially distributed, convection diffusion permeation reaction binding, blood-tissue exchange, oxygen, O2, carbon dioxide, CO2, HCO3-, HCO3, bicarbonate, hydrogen, H, transport, metabolism, myoglobin, hemoglobin, oxyhemoglobin, carbamino-hemoglobin, dissociation, 2,3-DPG, 2,3-diphosphoglycerate, 2,3-BPG, 2,3-bisphosphoglycerate, temperature
- Exchange_O2_CO2_HCO3_and_H
NSR0136 (in NSR archive): VSM_Ephys
The vascular smooth muscle cell electrophysiology model as developed by Kapela et al, 2008.
The vascular smooth muscle cell electrophysiology model as developed by Kapela et al, 2008.
- Key terms: calcium dynamics, gap junctions, ion channels, nitric oxide, microcirculation, arteriol smooth muscle, norepinephrine, vascular tone, electrophysiology, membrane potential, Publication
- VSM_Ephys
NSR0137 (in NSR archive): Renkin2region59
Models uptake of tracer potassium by skeletal muscle during continuous perfusion, flow constant or varied. Estimates the PS for the single composite barrier between axially distributed plasma and the cell potassium pool. (derived from model 0080)
Models uptake of tracer potassium by skeletal muscle during continuous perfusion, flow constant or varied. Estimates the PS for the single composite barrier between axially distributed plasma and the cell potassium pool. (derived from model 0080)
- Key terms: BTEX20, PDE, convection, diffusion, permeation, reaction, distributed, capillary, plasma, isf, interstitial fluid, Data
- Renkin2region59
NSR0143 (in NSR archive): Gao1998_ARD
The autoregulatory device (ARD) developed by Gao et al. is reproduced here to simulate the autoregulation of cerebral blood flow in the 300 to 50 micron diameter vessels.
The autoregulatory device (ARD) developed by Gao et al. is reproduced here to simulate the autoregulation of cerebral blood flow in the 300 to 50 micron diameter vessels.
- Key terms: Autoregulation, Cardiovascular System, Cerbral Blood Flow, Vascular Resistance, Microvasculature, Regulatory Response, Publication, PMID9530217
- Gao1998_ARD
NSR0144 (in NSR archive): Gas_Exch
Recirculation of O2 and CO2 between a 2-compartment lung and 2-compartment body.
Recirculation of O2 and CO2 between a 2-compartment lung and 2-compartment body.
- Key terms: Alveolar gas exchange, whole body metabolism, respiratory quotient, oxygen, carbon dioxide, cardiac output, plasma oxygen levels, plasma carbon dioxide, no buffering, no hemoglobin, gas solubilites in blood, air-blood gas exchange
- Gas_Exch
NSR0145 (in NSR archive): GasExch_Lu_2001
Model for O2, CO2, and N2 in airways and O2, CO2 in blood of circulating system. Lu et al 2001.
Model for O2, CO2, and N2 in airways and O2, CO2 in blood of circulating system. Lu et al 2001.
- Key terms: Respiratory System, air-blood gas exchange, oxygen, carbon dioxide, nitrogen, ventilation, breathing mechanics, diffusion, alveolar flux, Publication, Tutorial
- GasExch_Lu_2001
NSR0146 (in NSR archive): Crone63_BTEX
Models a tissue cylinder consisting of two regions: plasma, and interstitial fluid. Fit to Crone 1963 data.
Models a tissue cylinder consisting of two regions: plasma, and interstitial fluid. Fit to Crone 1963 data.
- Key terms: BTEX20, PDE, convection, diffusion, permeation, reaction, distributed, capillary, plasma, isf, interstitial fluid, Crone, Indicator dilution, sucrose, vascular reference, data
- Crone63_BTEX
NSR0147 (in NSR archive): Vessels_4RC
This model describes a flow through vessels with resistance to flow, and compliance. Model 'Vessel_2RC' has two RC vessels in series while 'Vessel4RC has two RC vessels in parallel with two RC vessels in series.
This model describes a flow through vessels with resistance to flow, and compliance. Model 'Vessel_2RC' has two RC vessels in series while 'Vessel4RC has two RC vessels in parallel with two RC vessels in series.
- Key terms: compliant, vessel, flow, resistance, compliance, RC circuit, Tutorial, Pressure volume, parallel RC
- Vessels_4RC
NSR0148 (in NSR archive): Lenbury2005.pituitary
A delay-differential equation model of the feedback/feedforward-controlled hypothalamus-pituitary-adrenal axis in humans. Lenbury and Pornsawad, 2005 paper.
A delay-differential equation model of the feedback/feedforward-controlled hypothalamus-pituitary-adrenal axis in humans. Lenbury and Pornsawad, 2005 paper.
- Key terms: adrenal cortex, anterior pituitary, cortisol, endocrine, hpa axis, hypothalamus, PMID15716298, Publication, ACTH, cellML
- Lenbury2005.pituitary
NSR0149 (in NSR archive): HbO2_HbCO2_diss
Blood HbO2 and HbCO2 Dissociation Curves at Varied O2, CO2, pH, 2,3-DPG and Temperature Levels. Based directly on Dash et al. 2010 errata reprint.
Blood HbO2 and HbCO2 Dissociation Curves at Varied O2, CO2, pH, 2,3-DPG and Temperature Levels. Based directly on Dash et al. 2010 errata reprint.
- Key terms: oxygen, O2, carbon dioxide, CO2, Hb, hemoglobin, oxyhemoglobin, carbamino-hemoglobin, dissociation curves, pH, 2,3-diphosphoglycerate, 2,3-DPG, 2,3-bisphosphoglycerate, 2,3-BPG, temperature effects, O2-CO2 interactions, Bohr effects, Haldane effects, Publication, matlab
- HbO2_HbCO2_diss
NSR0150 (in NSR archive): Shrestha_2010
Short term response of parathyroid gland to changes in plasma Ca(2+) levels. Based on Shrestha et al. 2010 paper.
Short term response of parathyroid gland to changes in plasma Ca(2+) levels. Based on Shrestha et al. 2010 paper.
- Key terms: Endocrine, calcium homeostasis, Ca, parathyroid hormone, bone, analytical model, CellML-derived, Data, Publication, PMID20406649
- Shrestha_2010